Skip to main content

Advertisement

SpringerLink
Log in

MYELOPROLIFERATIVE DISORDERS

Finding the right KIT inhibitor for advanced systemic mastocytosis

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Two early-phase clinical trials show impressive response rates and symptom improvement with the selective KIT inhibitor avapritinib, which will provide a much-needed new treatment option for patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: SM symptoms, mediators and organ impact of indolent and advanced disease.

References

  1. Valent, P., Akin, C. & Metcalfe, D. D. Blood 129, 1420–1427 (2017).

    Article  CAS  Google Scholar 

  2. Metcalfe, D. D. J. Invest. Dermatol. 96, 2S–4S (1991).

    Article  Google Scholar 

  3. Castells, M. & Austen, K. F. Int. Arch. Allergy Immunol. 127, 147–152 (2002).

    Article  CAS  Google Scholar 

  4. Theoharides, T. C., Valent, P. & Akin, C. N. Engl. J. Med. 373, 163–172 (2015).

    Article  CAS  Google Scholar 

  5. Escribano, L., Akin, C., Castells, M., Orfao, A. & Metcalfe, D. D. Ann. Hematol. 81, 677–690 (2002).

    Article  CAS  Google Scholar 

  6. Escribano, L. et al. J. Allergy Clin. Immunol. 124, 514–521 (2009).

    Article  Google Scholar 

  7. Lim, K. H. et al. Blood 113, 5727–5736 (2009).

    Article  CAS  Google Scholar 

  8. Nagata, H. et al. Proc. Natl Acad. Sci. USA 92, 10560–10564 (1995).

    Article  CAS  Google Scholar 

  9. DeAngelo, D. J. et al. Nat. Med. https://doi.org/10.1038/s41591-021-01538-9 (2021).

  10. Gotlib, J. et al. Nat. Med. https://doi.org/10.1038/s41591-021-01539-8 (2021).

  11. Gotlib, J. et al. N. Engl. J. Med. 374, 2530–2541 (2016).

    Article  CAS  Google Scholar 

  12. Castells, M. & Butterfield, J. J. Allergy Clin. Immunol. Pract. 7, 1097–1106 (2019).

    Article  Google Scholar 

  13. Akin et al. J. Allergy Clin. Immunol. 145, AB336 (2020).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Allergy and Clinical Immunology, Brigham and Women’s Hospital, Boston, MA, USA

    Mariana Castells

  2. Department of Medicine, Harvard Medical School, Boston, MA, USA

    Mariana Castells

  3. Division of Allergy and Immunology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

    Cem Akin

Authors
  1. Mariana Castells
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cem Akin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mariana Castells.

Ethics declarations

Competing interests

M.C. and C.A. have consultancy agreement with and receive research funding from Blueprint Medicines.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Castells, M., Akin, C. Finding the right KIT inhibitor for advanced systemic mastocytosis. Nat Med 27, 2081–2082 (2021). https://doi.org/10.1038/s41591-021-01588-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-021-01588-z

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation