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A novel pathway for microbial metabolism of levodopa

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Particular bacteria from the gut microbiota metabolize levodopa (l-dopa), reducing bioavailability of the drug for treating Parkinson’s disease.

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Fig. 1: Redkal et al. identify a novel pathway for microbial metabolism of l-dopa.

References

  1. Sampson, T. R. et al. Cell 167, 1469–1480.e12 (2016).

    Article  CAS  Google Scholar 

  2. Papavasiliou, P. S. et al. N. Engl. J. Med. 286, 8–14 (1972).

    Article  CAS  Google Scholar 

  3. Bedarf, J. R. et al. Genome Med. 9, 39 (2017).

    Article  CAS  Google Scholar 

  4. Hashim, H. et al. PLOS One 9, e112330 (2014).

    Article  Google Scholar 

  5. Fasano, A. et al. Mov. Disord. 28, 1241–1249 (2013).

    Article  CAS  Google Scholar 

  6. Zhu, H. et al. Sci. Rep. 6, 27779 (2016).

    Article  CAS  Google Scholar 

  7. Whitfield, A. C. et al. ACS Chem. Neurosci. 5, 1192–1197 (2014).

    Article  CAS  Google Scholar 

  8. Zimmermann, M. et al. Nature 570, 462–467 (2019).

    Article  CAS  Google Scholar 

  9. Zimmermann, M. et al. Science 363, 6427 (2019).

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Integrative Biology & Physiology, University of California Los Angeles, Los Angeles, CA, USA

    K. G. Jameson & E. Y. Hsiao

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  1. K. G. Jameson
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  2. E. Y. Hsiao
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Correspondence to K. G. Jameson.

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The authors declare no competing interests.

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Jameson, K.G., Hsiao, E.Y. A novel pathway for microbial metabolism of levodopa. Nat Med 25, 1195–1197 (2019). https://doi.org/10.1038/s41591-019-0544-x

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