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NEURODEGENERATION

Genetic characterization of amyloid-β and tau network spread

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Protein-specific and shared genetic pathways influence the spread of amyloid-β and tau pathology. Hence, distinct gene expression profiles may induce regional vulnerability of the human cortex to the specific proteinopathies of Alzheimer’s disease.

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Fig. 1: Genetically determined network spreading of amyloid-β and tau.

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Authors and Affiliations

  1. Lund University, Clinical Memory Research Unit, Lund, Sweden

    Rik Ossenkoppele & Oskar Hansson

  2. VU University Medical Center, Department of Neurology and Alzheimer Center, Amsterdam Neuroscience, Amsterdam, The Netherlands

    Rik Ossenkoppele

  3. Memory Clinic, Skåne University Hospital, Malmö, Sweden

    Oskar Hansson

Authors
  1. Rik Ossenkoppele
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  2. Oskar Hansson
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Correspondence to Rik Ossenkoppele or Oskar Hansson.

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The authors declare no competing interests.

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Ossenkoppele, R., Hansson, O. Genetic characterization of amyloid-β and tau network spread . Nat Med 24, 1790–1792 (2018). https://doi.org/10.1038/s41591-018-0277-2

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