Abstract
A neoadjuvant approach relying on the administration of combined anti-CTLA-4–anti-PD-1 treatment before lymph node surgery is evaluated in two phase 1 trials. Encouraging clinical, pathological and immunological responses to neoadjuvant therapy were observed, suggesting that this concept warrants further exploration; however, any future approach must address the unacceptably high toxicity of the regimens evaluated in these trials.
Similar content being viewed by others
References
Robert, C. et al. N. Engl. J. Med. 372, 30–39 (2015).
Robert, C. et al. N. Engl. J. Med. 372, 2521–2532 (2015).
Robert, C. et al. N. Engl. J. Med. 372, 320–330 (2015).
Robert, C. et al. J. Clin. Oncol. 36, 1668–1674 (2018).
Wolchok, J. D. et al. N. Engl. J. Med. 369, 122–133 (2013).
Eggermont, A. M. M. et al. N. Engl. J. Med. 378, 1789–1801 (2018).
Weber, J. et al. N. Engl. J. Med. 377, 1824–1835 (2017).
Amaria, R. N. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0197-1 (2018).
Blank, C. et al. Nat. Med. https://doi.org/10.1038/s41591-018-0198-0 (2018).
Chen, Y. et al. Medicine (Baltimore) 97, e10634 (2018).
MacLean, M. et al. Oncotarget 9, 24470–24479 (2018).
Wolchok, J. D. et al. Clin. Cancer Res. 15, 7412–7420 (2009).
Hodi, F. S. et al. J. Clin. Oncol. 34, 1510–1517 (2016).
Liu, J. et al. Cancer Discov. 6, 1382–1399 (2016).
Tetzlaff, M. T. et al. Ann. Oncol. 29, 1861–1868 (2018).
Hellmann, M. D. et al. N. Engl. J. Med. 378, 2093–2104 (2018).
Rizvi, N. A. et al. Science 348, 124–128 (2015).
Long, G. V. et al. N. Engl. J. Med. 377, 1813–1823 (2017).
Amaria, R. N. et al. Lancet Oncol. 19, 181–193 (2018).
Gershenwald J. E. et al. CA Cancer J. Clin. 67, 472–492 (2017).
Morton, D. L. et al. N. Engl. J. Med. 370, 599–609 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Additional information
Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Robert, C. Is earlier better for melanoma checkpoint blockade?. Nat Med 24, 1645–1648 (2018). https://doi.org/10.1038/s41591-018-0250-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41591-018-0250-0
- Springer Nature America, Inc.
This article is cited by
-
Immunotherapy discontinuation — how, and when? Data from melanoma as a paradigm
Nature Reviews Clinical Oncology (2020)
-
Ipilimumab plus nivolumab and chemoradiotherapy followed by surgery in patients with resectable and borderline resectable T3-4N0–1 non-small cell lung cancer: the INCREASE trial
BMC Cancer (2020)
-
New paradigm for stage III melanoma: from surgery to adjuvant treatment
Journal of Translational Medicine (2019)