The transient expression of CD61 and its unconventional pairing with CD103 at the immune synapse enhances T cell receptor signaling, improves anti-tumor cytotoxicity and mitigates tumor growth. Clinically, CD61+ tumor infiltrating lymphocytes (TILs) exhibit enhanced effector functions and show limited cellular exhaustion.
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This is a summary of: Hamid, M. H. B. A. et al. Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity. Nat. Immunol. https://doi.org/10.1038/s41590-024-01802-3 (2024).
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Transient synaptic CD61 pairing with CD103 increases the cytotoxicity of antigen-specific T cells. Nat Immunol 25, 739–740 (2024). https://doi.org/10.1038/s41590-024-01829-6
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DOI: https://doi.org/10.1038/s41590-024-01829-6
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