In this study, we use a transcriptomic approach as a starting point to explore the heterogeneity of human GATA3-expressing lymphocytes across different tissues and disease contexts. We identify, characterize and functionally validate an abundant progenitor-like memory T cell population with the potential to sustain pathogenic TH2 cell inflammation.
This is a preview of subscription content, log in via an institution to check access.
References
Wambre, E. et al. A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders. Sci. Transl. Med. 9, eaam9171 (2017). This paper describes a subset of cytokine-producing effector TH2 cells associated with allergic disease in humans.
Upadhyaya, B., Yin, Y., Hill, B. J., Douek, D. C. & Prussin, C. Hierarchical IL-5 expression defines a subpopulation of highly differentiated human Th2 cells. J. Immunol. 187, 3111–3120 (2011). This work was the first description of a human highly differentiated, cytokine-producing TH2 cell effector subset.
Gowthaman, U. et al. Identification of a T follicular helper cell subset that drives anaphylactic IgE. Science 365, eaaw6433 (2019). This paper describes a population of follicular helper T cells that is critical for high-affinity IgE production in allergic disease.
Philip, M. & Schietinger, A. CD8+ T cell differentiation and dysfunction in cancer. Nat. Rev. Immunol. 22, 209–223 (2022). This review provides an outstanding overview of the paradigms that have developed to explain the hyporesponsive and stem-like progenitor T cells states observed in cancer.
Ma, J. et al. Single-cell analysis pinpoints distinct populations of cytotoxic CD4+ T cells and an IL-10+CD109+ TH2 cell population in nasal polyps. Sci. Immunol. 6, eabg6356 (2021). This study used a single-cell transcriptomic approach to uncover T cell diversity in human nasal polyposis.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Kratchmarov, R. et al. TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases. Nat. Immunol. https://doi.org/10.1038/s41590-024-01803-2 (2024).
Rights and permissions
About this article
Cite this article
Identification of a human multipotent TH2 progenitor. Nat Immunol 25, 735–736 (2024). https://doi.org/10.1038/s41590-024-01818-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-024-01818-9
- Springer Nature America, Inc.