Homeostatic immune cells remain perpetually vigilant against pathogens. We found that baseline JAK–STAT signaling supports the characteristic transcriptional and epigenetic state of homeostatic T cells and macrophages in mice. JAK–STAT signaling under homeostatic conditions was driven by signals from healthy tissue and did not require external immune stimuli.
This is a preview of subscription content, log in via an institution to check access.
References
Philips, R. L. et al. The JAK-STAT pathway at 30: Much learned, much more to do. Cell 185, 3857–3876 (2022). A review of what we know and what we do not (yet) know about JAK–STAT signaling, 30 years after the pathway’s discovery.
Taniguchi, T. & Takaoka, A. A weak signal for strong responses: interferon-α/β revisited. Nat. Rev. Mol. Cell Biol. 2, 378–386 (2001). A review on low-level interferon signaling in the absence of pathogenic challenge as a preparation for strong signaling responses.
Krausgruber, T. et al. Structural cells are key regulators of organ-specific immune responses. Nature 583, 296–302 (2020). Analysis of transcriptomes and chromatin accessibility in structural cells uncovers an epigenetic potential at immune genes.
Schwartz, D. M. et al. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases. Nat. Rev. Drug Discov. 17, 78 (2017). A review of JAK–STAT pathway-associated diseases and the potential for therapeutic targeting of JAK–STAT signaling.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Fortelny, N. et al. JAK-STAT signaling maintains homeostasis in T cells and macrophages. Nat. Immunol. https://doi.org/10.1038/s41590-024-01804-1 (2024).
Rights and permissions
About this article
Cite this article
Baseline JAK–STAT signaling maintains immune cell homeostasis. Nat Immunol 25, 741–742 (2024). https://doi.org/10.1038/s41590-024-01805-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-024-01805-0
- Springer Nature America, Inc.