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Immune dysregulation in long COVID

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Profiling of plasma proteins in individuals with COVID-19 shows that complement activation and myeloid inflammation are major pathways in the pathogenesis of long COVID and identifies distinct profiles of immune dysregulation in individuals with long COVID, highlighting the heterogeneous and diverse nature of this disease.

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Fig. 1: Mechanisms that could underlie the different manifestations of long COVID.

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Acknowledgements

We thank T. Hoch and A. Nicoletto for reading the manuscript. Funding was provided by Swiss National Science Foundation grants (4078P0-198431, 310030-200669 and 310030-212240 to O.B.).

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Authors and Affiliations

  1. Department of Immunology, University of Zurich, University Hospital Zurich, Zurich, Switzerland

    Laura Ceglarek & Onur Boyman

  2. Faculty of Medicine and Faculty of Science, University of Zurich, Zurich, Switzerland

    Onur Boyman

Authors
  1. Laura Ceglarek
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  2. Onur Boyman
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Corresponding author

Correspondence to Onur Boyman.

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Competing interests

O.B. is listed as an inventor on a patent application (PCT/EP2023/084859) on biomarkers in long COVID. L.C. has no competing interests.

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Ceglarek, L., Boyman, O. Immune dysregulation in long COVID. Nat Immunol 25, 587–589 (2024). https://doi.org/10.1038/s41590-024-01795-z

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