DNA sensing for the purposes of innate immunity is tricky when the DNA sensor can easily become stuck on chromosomes during cell division. The mechanism by which the trapped DNA sensor is degraded — and how this process can be balanced with added immune protection — is now reported.
This is a preview of subscription content, log in via an institution to check access.
References
Ablasser, A. & Chen, Z. J. Science 363, eaat8657 (2019).
de Oliveira Mann, C. C. & Hopfner, K. P. EMBO J. 40, e108293 (2021).
Yang, H., Wang, H., Ren, J., Chen, Q. & Chen, Z. J. Proc. Natl Acad. Sci. USA 114, E4612–E4620 (2017).
Gentili, M. et al. Cell Rep. 26, 2377–2393.e13 (2019).
Xu, P. et al. Nature https://doi.org/10.1038/s41586-024-07112-w (2024).
Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J. Science 339, 786–791 (2013).
Zierhut, C. et al. Cell 178, 302–315.e32 (2019).
Zhao, Y., Xiong, X. & Sun, Y. Semin. Cancer Biol. 67, 61–79 (2020).
Orzalli, M. H. et al. Proc. Natl Acad. Sci. USA 112, E1773–E1781 (2015).
Lahaye, X. et al. Cell 175, 488–501.e22 (2018).
Cho, M. G. et al. Nature 625, 585–592 (2024).
Volkman, H. E., Cambier, S., Gray, E. E. & Stetson, D. B. Elife 8, e47491 (2019).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Leonen, C.J.A., Funabiki, H. cGAS meets its demise in the nucleus. Nat Immunol 25, 592–593 (2024). https://doi.org/10.1038/s41590-024-01794-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-024-01794-0
- Springer Nature America, Inc.