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Liver immunity

Unveiling the antitumor function of ID3 in liver macrophages

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A landmark study reveals how Kupffer cells, resident macrophages of the liver, can promote antitumor immunity. Central to this function is ID3, a Kupffer cell lineage-determining factor. The findings provide new insights into cancer therapy.

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Fig. 1: KCs, liver-resident macrophages, are endowed with natural antitumor capabilities promoted by ID3.

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Authors and Affiliations

  1. Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland

    Anne-Gaëlle Goubet & Mikaël J. Pittet

  2. AGORA Cancer Research Center, Swiss Cancer Center Leman, Lausanne, Switzerland

    Anne-Gaëlle Goubet & Mikaël J. Pittet

  3. Ludwig Institute for Cancer Research, Lausanne, Switzerland

    Mikaël J. Pittet

  4. Department of Oncology, Geneva University Hospitals (HUG), Geneva, Switzerland

    Mikaël J. Pittet

Authors
  1. Anne-Gaëlle Goubet
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  2. Mikaël J. Pittet
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Corresponding author

Correspondence to Mikaël J. Pittet.

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Competing interests

M.J.P. has served as a consultant for AstraZeneca, Elstar Therapeutics, ImmuneOncia, KSQ Therapeutics, LegoChem Bio, Merck, Siamab Therapeutics, Third Rock Ventures, Tidal and Unikum.

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Goubet, AG., Pittet, M.J. Unveiling the antitumor function of ID3 in liver macrophages. Nat Immunol 25, 394–395 (2024). https://doi.org/10.1038/s41590-024-01761-9

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  • DOI: https://doi.org/10.1038/s41590-024-01761-9

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