In this proof-of-concept study, we present a next-generation poxvirus vaccine that features a ‘two-in-one’ immunogen. Our protein vaccine construct, DAM, combines the monkeypox virus antigens A35 and M1, and was produced on the basis of structure-guided design. The DAM subunit vaccine elicited superior antiviral immunity with safety compared to cocktail vaccines or a live vaccinia virus vaccine.
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This is a summary of: Wang, H. et al. Rational design of a ‘two-in-one’ immunogen DAM drives potent immune response against monkeypox virus. Nat. Immunol. https://doi.org/10.1038/s41590-023-01715-7 (2024).
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Building a next-generation, two-component protein subunit vaccine against monkeypox virus. Nat Immunol 25, 200–201 (2024). https://doi.org/10.1038/s41590-023-01735-3
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DOI: https://doi.org/10.1038/s41590-023-01735-3
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