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T cell memory

Releasing the TLE3 break to put TCM cells on a fast track

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The transcription cofactor TLE3 interacts with RUNX3 and TCF1 to repress the transcription and chromatin accessibility of CD8+ TCM cell signature genes, while simultaneously acting as a coactivator for TBET to facilitate the expression of CD8+ TEM cell signature genes. As such, TLE3 serves as a gatekeeper of CD8+ TCM cell formation.

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Fig. 1: TLE3 has a dual role in regulating CD8+ T cell memory differentiation.

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Authors and Affiliations

  1. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Jian Shen, Siying Lin & Weiguo Cui

  2. Department of Microbiology and Immunology, Medical College of Wisconsin, Milwaukee, WI, USA

    Siying Lin

Authors
  1. Jian Shen
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  2. Siying Lin
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  3. Weiguo Cui
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Correspondence to Weiguo Cui.

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The authors declare no competing interests.

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Shen, J., Lin, S. & Cui, W. Releasing the TLE3 break to put TCM cells on a fast track. Nat Immunol 25, 191–193 (2024). https://doi.org/10.1038/s41590-023-01732-6

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  • DOI: https://doi.org/10.1038/s41590-023-01732-6

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