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Type 1 or type 2 lineage-specific promoters regulate expression of the IL-33 receptor in T cells

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The alarmin IL-33 activates type 1 and type 2 immune cells via its receptor ST2 in a context-specific manner. We discovered a type 1 immunity-restricted promoter of the ST2-coding gene Il1rl1, which is located far upstream of the curated gene and is crucial for antiviral CD8+ cytotoxic T cell and CD4+ TH1 cell responses.

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Fig. 1: A type 1 immunity-restricted Il1rl1 promoter drives differentiation and expansion of antiviral short-lived effector CTLs.

References

  1. Schmitz, J. et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23, 479–490 (2005). This paper reports on the identification of IL-33 as the ligand for ST2 and highlights its importance in type 2 immunity.

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This is a summary of: Brunner, T. M. et al. A type 1 immunity-restricted promoter of the IL-33 receptor gene directs antiviral T-cell responses. Nat. Immunol. https://doi.org/10.1038/s41590-023-01697-6 (2024).

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Type 1 or type 2 lineage-specific promoters regulate expression of the IL-33 receptor in T cells. Nat Immunol 25, 204–205 (2024). https://doi.org/10.1038/s41590-023-01706-8

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  • DOI: https://doi.org/10.1038/s41590-023-01706-8

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