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Inflammatory bowel disease

Interferon-γ sensing by epithelial cells tames gut inflammation

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Epithelial cells, macrophages and T cells are linked in a previously unknown regulatory circuit. Sensing of interferon-γ triggers antigen presentation by colonic epithelial cells, enabling T cells to lower extracellular ATP levels and reduce inflammation.

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Fig. 1: IFNγ signaling in epithelial cells tames gut inflammation.

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Acknowledgements

This work was supported by the German Research Foundation (DFG), project ID 403224013–SFB 1382 (B06) and DFG PA921/8-1.

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  1. Institute of Molecular Medicine, RWTH Aachen University, Aachen, Germany

    Oliver Pabst & Vuk Cerovic

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  1. Oliver Pabst
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  2. Vuk Cerovic
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Correspondence to Oliver Pabst.

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The authors declare no competing interests.

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Pabst, O., Cerovic, V. Interferon-γ sensing by epithelial cells tames gut inflammation. Nat Immunol 25, 9–10 (2024). https://doi.org/10.1038/s41590-023-01705-9

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