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Treg cells

IL-27 gives a good gut feeling about immune regulation

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Regulatory T (Treg) cells maintain the balance between immune protection and pathology. Research has now found that intestinal Treg cells produce IL-27 to restrain TH17 cell-mediated immune responses, effectively restricting autoimmune inflammation and limiting T cell responses to certain gut pathogens.

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Fig. 1: Gut inflammation drives Treg production of the immunoregulatory cytokine IL-27.

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Authors and Affiliations

  1. Department of Immunobiology, Yale University, New Haven, CT, USA

    Emily R. Siniscalco & Joe Craft

  2. Department of Internal Medicine, Yale University, New Haven, CT, USA

    Joe Craft

Authors
  1. Emily R. Siniscalco
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  2. Joe Craft
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Correspondence to Emily R. Siniscalco or Joe Craft.

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The authors declare no competing interests.

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Siniscalco, E.R., Craft, J. IL-27 gives a good gut feeling about immune regulation. Nat Immunol 24, 1972–1973 (2023). https://doi.org/10.1038/s41590-023-01683-y

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  • DOI: https://doi.org/10.1038/s41590-023-01683-y

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