Two new studies in which apoE expression in mice is manipulated provide insights into the roles of microglial apoE in neurodegeneration.
References
Wu, L., Zhang, X. & Zhao, L. J. Neurosci. 38, 6665–6681 (2018).
Liu, C.-C. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01640-9 (2023).
Yin, Z. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01627-6 (2023).
Prinz, M., Masuda, T., Wheeler, M. A. & Quintana, F. J. Annu. Rev. Immunol. 39, 251–277 (2021).
Prinz, M., Jung, S. & Priller, J. Cell 179, 292–311 (2019).
Fullerton, S. M. et al. Am. J. Hum. Genet. 67, 881–900 (2000).
Krasemann, S. et al. Immunity 47, 566–581 e569 (2017).
Edwards, J. P., Thornton, A. M. & Shevach, E. M. J. Immunol. 193, 2843–2849 (2014).
Goldmann, T. et al. Nat. Immunol. 17, 797–805 (2016).
Faust, T. E. et al. Cell. Rep. 42, 113031 (2023).
Komor, A. C., Kim, Y. B., Packer, M. S., Zuris, J. A. & Liu, D. R. Nature 533, 420–424 (2016).
Simard, A. R., Soulet, D., Gowing, G., Julien, J. P. & Rivest, S. Neuron 49, 489–502 (2006).
Acknowledgements
M.P. is supported by the Sobek Foundation, the Ernst–Jung Foundation, the Klaus Faber Foundation, the Novo Nordisk Prize, the German Research Foundation (SFB 992 project ID 192904750, SFB 1160, SFB 1479 project ID 441891347, TRR 359 project ID 491676693, SFB/TRR167 Project ID259373024 NeuroMac and Gottfried Wilhelm Leibniz Prize) and by the DFG under Germany’s Excellence Strategy (CIBSS – EXC-2189 – project ID390939984).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Wogram, E., Prinz, M. APOE set the microglia free. Nat Immunol 24, 1790–1791 (2023). https://doi.org/10.1038/s41590-023-01651-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41590-023-01651-6
- Springer Nature America, Inc.