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Cancer immunology

An adrenaline kick to exhaust T cells

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For decades, beta-blockers have been used widely to treat cardiovascular diseases. Surprisingly, new data show how these inhibitors can also improve immunotherapy against tumors and chronic infections.

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Fig. 1: β-adrenergic signaling drives terminal differentiation and exhaustion of T cells.

References

  1. Zehn, D., Thimme, R., Lugli, E., de Almeida, G. P. & Oxenius, A. Nat. Immunol. 23, 836–847 (2022).

    Article  CAS  PubMed  Google Scholar 

  2. Utzschneider, D. T. et al. J. Exp. Med. 213, 1819–1834 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. Annu. Rev. Immunol. 37, 457–495 (2019).

    Article  CAS  PubMed  Google Scholar 

  4. Globig, A. et al. Nature https://doi.org/10.1038/s41586-023-06568-6 (2023).

  5. Alfei, F. et al. Nature 571, 265–269 (2019).

    Article  CAS  PubMed  Google Scholar 

  6. Khan, O. et al. Nature 571, 211–218 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Scott, A. C. et al. Nature 571, 270–274 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Yao, C. et al. Nat. Immunol. 20, 890–901 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Skaper, S. D. Immunology 151, 1–15 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Wu, V. H. et al. Nat. Immunol. 24, 1318–1330 (2023).

    Article  CAS  PubMed  Google Scholar 

  11. Nissen, M. D., Sloan, E. K. & Mattarollo, S. R. Cancer Immunol. Res. 6, 98–109 (2018).

    Article  CAS  PubMed  Google Scholar 

  12. Estrada, L. D., Agac, D. & Farrar, J. D. Eur. J. Immunol. 46, 1948–1958 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Center for Infection Prevention (Zentrum für Infektionsprävention, ZIP), Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany

    Jacqueline Berner & Dietmar Zehn

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  1. Jacqueline Berner
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  2. Dietmar Zehn
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Correspondence to Dietmar Zehn.

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The authors declare no competing interests.

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Berner, J., Zehn, D. An adrenaline kick to exhaust T cells. Nat Immunol 24, 1792–1793 (2023). https://doi.org/10.1038/s41590-023-01650-7

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