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Disorder-based T cell developmental order

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Many transcription factors contain intrinsically disordered regions whose functions are not well characterized. An intrinsically disordered region in TCF-1 has now been found to have an essential function in coordinating T cell lineage commitment.

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Fig. 1: The L1 region of TCF-1 is involved in the differential regulation of cell lineage genes.

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Authors and Affiliations

  1. Laboratory of Epigenome Biology, Systems Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA

    Shuai Liu & Keji Zhao

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  1. Shuai Liu
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  2. Keji Zhao
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Correspondence to Keji Zhao.

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The authors declare no competing interests.

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Liu, S., Zhao, K. Disorder-based T cell developmental order. Nat Immunol 24, 1602–1603 (2023). https://doi.org/10.1038/s41590-023-01623-w

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