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Tumor immunology

The road not taken en route to T cell exhaustion

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The first detailed investigation of CD8+ tumor-infiltrating T cell differentiation in the hours after cells enter a tumor has yielded an unexpected twist. Naive T cells veer away from effector fate and enter the path towards exhaustion much earlier than expected.

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Fig. 1: En route to CD8+ T cell exhaustion.

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Acknowledgements

The authors thank A. Rao for comments. P.G.H. acknowledges support from National Institutes of Health (NIH) grants AI040127 and AI109842, and La Jolla Institute for Immunology institutional funds. B.D. is a Cancer Research Institute Irvington fellow supported by the Cancer Research Institute (CRI4681).

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Authors and Affiliations

  1. La Jolla Institute for Immunology, La Jolla, CA, USA

    Barsha Dash & Patrick G. Hogan

  2. Moores Cancer Center, University of California San Diego, La Jolla, CA, USA

    Patrick G. Hogan

  3. Program in Immunology, University of California San Diego, La Jolla, CA, USA

    Patrick G. Hogan

Authors
  1. Barsha Dash
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  2. Patrick G. Hogan
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Correspondence to Patrick G. Hogan.

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Competing interests

P.G.H. is a founder of CalciMedica, Inc, and serves on its scientific advisory board. B.D. has no competing interests to disclose.

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Dash, B., Hogan, P.G. The road not taken en route to T cell exhaustion. Nat Immunol 24, 1402–1404 (2023). https://doi.org/10.1038/s41590-023-01596-w

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