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Alt-RNAtive vaccines elicit anti-malarial TRM cells

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Malaria is a vector-borne disease caused by Plasmodium parasites. In an exciting new study, Ganley et al. harness the power of mRNA vaccines to summon tissue-resident memory T cells to battle the parasite as it replicates in the liver.

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Fig. 1: Incorporation of modified α-GalCer in LNPs promotes the formation of anti-malarial liver TRM cells and parasite clearance.

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Authors and Affiliations

  1. Department of Pathology, University of Iowa–Carver College of Medicine, Iowa City, IA, USA

    Mariah Hassert & John T. Harty

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  1. Mariah Hassert
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  2. John T. Harty
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Correspondence to John T. Harty.

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The authors declare no competing interests.

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Hassert, M., Harty, J.T. Alt-RNAtive vaccines elicit anti-malarial TRM cells. Nat Immunol 24, 1397–1398 (2023). https://doi.org/10.1038/s41590-023-01594-y

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