Skip to main content
SpringerLink
Log in

T cell development

Doubling down to make killer T cells

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Control of the alternative commitment of immature CD4+CD8+ T cells to the CD4+ or CD8+ lineage has long been the subject of intense scrutiny. A combination of CITE-seq and functional assays provides significant new insights into the distinct T cell antigen receptor signaling requirements for these lineage fates.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Distinct TCR signaling requirements for commitment of immature double-positive CD4+CD8+ cells to the single-positive CD4+ or CD8+ lineage.

References

  1. Steier, Z. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01584-0 (2023).

    Article  PubMed  Google Scholar 

  2. Lucas, B. & Germain, R. N. Immunity 5, 461–477 (1996).

    Article  CAS  PubMed  Google Scholar 

  3. Suzuki, H., Punt, J. A., Granger, L. G. & Singer, A. Immunity 2, 413–425 (1995).

    Article  CAS  PubMed  Google Scholar 

  4. Bosselut, R., Guinter, T. I., Sharrow, S. O. & Singer, A. J. Exp. Med. 197, 1709–1719 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Brugnera, E. et al. Immunity 13, 59–71 (2000).

    Article  CAS  PubMed  Google Scholar 

  6. Adachi, S. & Iwata, M. Cell Immunol. 215, 45–53 (2002).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA, USA

    Dietmar Kappes & David L. Wiest

Authors
  1. Dietmar Kappes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David L. Wiest
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dietmar Kappes.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kappes, D., Wiest, D.L. Doubling down to make killer T cells. Nat Immunol 24, 1407–1408 (2023). https://doi.org/10.1038/s41590-023-01593-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-023-01593-z

  • Springer Nature America, Inc.

Search

Navigation