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Human immunology

The case for BALT in human respiratory immunity

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Bronchus-associated lymphoid tissue (BALT), which develops in the lung during infancy before declining over childhood, supports localized immune reactions against airway infections in early life including the generation of germinal center-like B cells specific for respiratory pathogens.

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Fig. 1: Distinct cellular composition and antigen reactivities of BALT B cell immunity in early life.

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Authors and Affiliations

  1. Department of Immunology, Monash University, Melbourne, Victoria, Australia

    Zhoujie Ding & David Tarlinton

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  1. Zhoujie Ding
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  2. David Tarlinton
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Correspondence to David Tarlinton.

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The authors declare no competing interests.

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Ding, Z., Tarlinton, D. The case for BALT in human respiratory immunity. Nat Immunol 24, 1220–1221 (2023). https://doi.org/10.1038/s41590-023-01566-2

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