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Fibrin induces neurotoxic microglia gene programs in neurodegeneration

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Extravasation of blood into the brain and activation of innate immune cells are hallmarks and therapeutic targets in neurological diseases. We show that specific blood proteins induce distinct receptor-mediated gene programs in microglia and that the blood coagulation protein fibrin has a causal role in pathogenic innate immunity in models of neurological diseases.

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Fig. 1: Fibrin is necessary for neurotoxic microglia gene expression.

References

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This is a summary of: Mendiola, A. S. et al. Defining blood-induced microglia functions in neurodegeneration through multiomic profiling. Nat. Immunol. https://doi.org/10.1038/s41590-023-01522-0 (2023).

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Fibrin induces neurotoxic microglia gene programs in neurodegeneration. Nat Immunol 24, 1062–1063 (2023). https://doi.org/10.1038/s41590-023-01542-w

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