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HLA polymorphisms

Oyez, Oyez, Oyez!

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Presentation of signal peptides by HLA-E to natural killer cells prevents cell lysis via interactions with the inhibitory CD94–NKG2A receptor. A study now reveals an unexpected level of sophistication and heterogeneity in this receptor–ligand interaction.

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Fig. 1: Recognition of HLA-E–signal peptide complexes by CD94–NKG2A.

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Acknowledgements

During the drafting of the article, Brinley John, the father of Jamie Rossjohn, passed away.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia

    Philippa M. Saunders & Andrew G. Brooks

  2. Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Melbourne, Australia

    Jamie Rossjohn

  3. Institute of Infection and Immunity, Cardiff University, School of Medicine, Cardiff, UK

    Jamie Rossjohn

Authors
  1. Philippa M. Saunders
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  2. Andrew G. Brooks
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  3. Jamie Rossjohn
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Corresponding author

Correspondence to Jamie Rossjohn.

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The authors declare no competing interests.

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Saunders, P.M., Brooks, A.G. & Rossjohn, J. Oyez, Oyez, Oyez!. Nat Immunol 24, 1052–1053 (2023). https://doi.org/10.1038/s41590-023-01541-x

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