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TH9 cells

JAKing up IL-9 expression in TH9 cells

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Bystander activation that leads to expression of IL-9 in effector TH9 cells is induced by a TCR-independent, STAT-dependent mechanism and may represent a new strategy for therapeutic intervention to treat TH9-induced pathologies in vivo.

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Fig. 1: Bystander activation of resting TH9 cells by IL-2 and IL-4 promotes IL9 expression and TH9-driven inflammation in vivo.

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Acknowledgements

This work was supported by the Consejo Nacional de Ciencia y Tecnología (CONACYT) grant FORDECYT-PRONACE-303027 and DGAPA (IN220823-PAPIIT) to P.L.L. O.M.P received a fellowship from CONACYT (736162). We thank S. Erickson and I. Licona-Limón for critical reading of the manuscript.

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  1. Departamento de Biología Celular y del Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México City, México

    Ofelia Muñoz-Paleta & Paula Licona-Limón

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  1. Ofelia Muñoz-Paleta
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  2. Paula Licona-Limón
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Correspondence to Paula Licona-Limón.

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Muñoz-Paleta, O., Licona-Limón, P. JAKing up IL-9 expression in TH9 cells. Nat Immunol 24, 891–892 (2023). https://doi.org/10.1038/s41590-023-01509-x

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