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Macrophage niche availability enables local monocyte proliferation in peripheral tissues

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Mononuclear phagocyte proliferation is thought to be limited to myeloid progenitor cells and mature macrophages. However, availability within an interstitial macrophage niche permits the proliferation of monocytes in the lung before macrophage differentiation.

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Fig. 1: Repopulation of lung IMs depends in part on proliferation of blood monocytes, before they differentiate into mature macrophages.

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Author information

Authors and Affiliations

  1. Department of Immunology, University of Toronto, Toronto, Ontario, Canada

    Aniqa B. Khan & Clinton S. Robbins

  2. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

    Clinton S. Robbins

  3. Peter Munk Cardiac Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada

    Clinton S. Robbins

Authors
  1. Aniqa B. Khan
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  2. Clinton S. Robbins
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Correspondence to Clinton S. Robbins.

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The authors declare no competing interests.

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Khan, A.B., Robbins, C.S. Macrophage niche availability enables local monocyte proliferation in peripheral tissues. Nat Immunol 24, 743–745 (2023). https://doi.org/10.1038/s41590-023-01482-5

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