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Inflammasomes

Ten things to know about NLRP10

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The NLRP10 protein is found to form an inflammasome complex in response to mitochondrial damage. Loss of NLRP10 from colonic epithelia promotes inflammatory bowel disease in a mouse model, while a variant predisposing to atopic dermatitis also shows loss of function.

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Fig. 1: 3m3-FBS activates the NLRP10 inflammasome via damaged mitochondria.

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Authors and Affiliations

  1. Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia

    Seth L. Masters

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  1. Seth L. Masters
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Correspondence to Seth L. Masters.

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Competing interests

S.L.M. is a scientific advisor for Odyssey Therapeutics and NRG Therapeutics.

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Masters, S.L. Ten things to know about NLRP10. Nat Immunol 24, 561–562 (2023). https://doi.org/10.1038/s41590-023-01466-5

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