Intrathymic dendritic cell (DC)-biased precursors act as hematopoietic stromal cells that support the generation of human T cell progenitors from hematopoietic progenitor cells, via crosstalk with immature thymocytes that express TNF receptor 2. This function of DC precursors can be exploited to generate T cell precursors and competent T cells for cell therapy.
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This is a summary of: Liang, K. L. et al. Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF. Nat. Immunol. https://doi.org/10.1038/s41590-022-01417-6 (2023).
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Dendritic cell-biased precursors support early human thymopoiesis. Nat Immunol 24, 389–390 (2023). https://doi.org/10.1038/s41590-023-01421-4
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DOI: https://doi.org/10.1038/s41590-023-01421-4
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