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IL-1α-releasing TH17 cells live long and prosper

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TH17 cells combat infection but can also drive pathological inflammation. A TH17 cell NLRP3–caspase-8–caspase-3–GSDME axis is now shown to release the alarmin IL-1α without triggering cell death.

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Fig. 1: TH17 TCR signaling induces and releases IL-1α via NLRP3 and GSDME in the absence of cell death.

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Authors and Affiliations

  1. The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

    Joanna R. Groom & James E. Vince

  2. The Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia

    Joanna R. Groom & James E. Vince

Authors
  1. Joanna R. Groom
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  2. James E. Vince
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Correspondence to Joanna R. Groom or James E. Vince.

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The authors declare no competing interests

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Groom, J.R., Vince, J.E. IL-1α-releasing TH17 cells live long and prosper. Nat Immunol 24, 205–206 (2023). https://doi.org/10.1038/s41590-022-01412-x

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