The inhibitory checkpoint molecule CTLA-4 is essential for regulatory T cell function. A new study highlights the differential manner in which CTLA-4 binds CD80 and CD86, which determines its cellular fate and orchestrates immune tolerance regulation.
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Humphries, P.A., Lo, WL. Two CTLA-4 ligands, separate pHates. Nat Immunol 23, 1297–1299 (2022). https://doi.org/10.1038/s41590-022-01296-x
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DOI: https://doi.org/10.1038/s41590-022-01296-x
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