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MECHANOIMMUNOLOGY

Mechanics drive lymph node expansion

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Multistep mechanosensing of lymphocyte infiltration and proliferation by the remodeling stroma and matrix underlies the immensely rapid and massive tissue expansion by lymph nodes in response to immune challenge.

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Fig. 1: Mechanics-driven expansion of the reactive lymph node.

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Authors and Affiliations

  1. George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA

    Yunus Alapan & Susan N. Thomas

  2. Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA

    Yunus Alapan & Susan N. Thomas

  3. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA

    Susan N. Thomas

  4. Winship Cancer Institute, Emory University, Atlanta, GA, USA

    Susan N. Thomas

Authors
  1. Yunus Alapan
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  2. Susan N. Thomas
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Correspondence to Susan N. Thomas.

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Alapan, Y., Thomas, S.N. Mechanics drive lymph node expansion. Nat Immunol 23, 1139–1141 (2022). https://doi.org/10.1038/s41590-022-01277-0

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  • DOI: https://doi.org/10.1038/s41590-022-01277-0

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