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Extrathymic Aire primes Candida-specific TH17 cells

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Extrathymic MHCII+Rorc+ Aire-expressing cells that share characteristics with type 3 innate lymphoid cells (ILC3s) internalize C. albicans and present its antigens, priming the development of Candida-specific TH17 cells.

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Fig. 1: Thymic and extrathymic expression and function of Aire.

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Acknowledgements

This work was supported by the Division of Intramural Research of the NIAID (ZIA AI001175 to M.S.L.).

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Authors and Affiliations

  1. Fungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy & Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA

    Vasileios Oikonomou & Michail S. Lionakis

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  1. Vasileios Oikonomou
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  2. Michail S. Lionakis
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Correspondence to Michail S. Lionakis.

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The authors declare no competing interests.

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Oikonomou, V., Lionakis, M.S. Extrathymic Aire primes Candida-specific TH17 cells. Nat Immunol 23, 997–999 (2022). https://doi.org/10.1038/s41590-022-01252-9

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