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Gasdermin D pores for IL-33 release

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In airway epithelial cells, exposure to allergen proteases induces the stress granules-mediated transfer of IL-33 from the nucleus to the cytoplasm and extracellular release through gasdermin D pores containing a newly described active fragment.

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Fig. 1: Dual functions of gasdermin D (GSDMD) in mediating extracellular release of IL-1 family molecules.

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Authors and Affiliations

  1. Division of Allergic Diseases and Department of Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA

    Hirohito Kita

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  1. Hirohito Kita
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Correspondence to Hirohito Kita.

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Kita, H. Gasdermin D pores for IL-33 release. Nat Immunol 23, 989–991 (2022). https://doi.org/10.1038/s41590-022-01249-4

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