Skip to main content

Advertisement

SpringerLink
Log in

TRANSGENERATIONAL IMMUNITY

Reimagining an immunological dogma

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Infections are known to induce epigenetic rewiring in myeloid cells, a phenomenon known as trained immunity, which protects against re-infection. New data show that, in mice, trained immunity can be inherited, possibly by gametic DNA methylation and chromatin remodeling linked to immune traits.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Inheritance of trained immunity.

References

  1. Netea, M. G. et al. Nat. Rev. Immunol. 20, 375–388 (2020).

    Article  CAS  Google Scholar 

  2. Katzmarski, N. et al. Nat. Genet. https://doi.org/10.1038/s41590-021-01052-7 (2021).

  3. Richards, E. J. Nat. Rev. Genet. 7, 395–401 (2006).

    Article  CAS  Google Scholar 

  4. Remy, J. J. Curr. Biol. 20, R877–R878 (2010).

    Article  CAS  Google Scholar 

  5. Heard, E. & Martienssen, R. A. Cell 157, 95–109 (2014).

    Article  CAS  Google Scholar 

  6. Stegemann, R. & Buchner, D. A. Semin. Cell Dev. Biol. 43, 131–140 (2015).

    Article  CAS  Google Scholar 

  7. Berendsen, M. et al. EClinicalMedicine 39, 101049 (2021).

    Article  Google Scholar 

  8. Leentjens, J. et al. Circ. Res. 122, 664–669 (2018).

    Article  CAS  Google Scholar 

  9. De Rosa, V., La Cava, A. & Matarese, G. Nat. Immunol. 18, 1190–1196 (2017).

    Article  Google Scholar 

  10. DeFalco, T. et al. Cell Rep. 12, 1107–1119 (2015).

    Article  CAS  Google Scholar 

  11. Bard, J. B. Cell Commun. Signal. 9, 30 (2011).

    Article  Google Scholar 

  12. Rechavi, O., Minevich, G. & Hobert, O. Cell 147, 1248–1256 (2011).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

G.M. is funded by Fondazione Italiana Sclerosi Multipla (FISM; grants 2016/R/18 and 2018/S/5), Progetti di Rilevante Interesse Nazionale (PRIN; grant 2017 K55HLC 001), and Ministero della Salute (grant RF-2019-12371111). P.d.C. is supported by the National Multiple Sclerosis Society (NMSS; grant PP-1606-24687), FISM (grants 2016/R/10 and 2018/R/4), and the Juvenile Diabetes Research Foundation (JDRF; grant 1-SRA-2018-477-S-B). We thank F. Prattichizzo for critically reviewing the manuscript and S. Bruzzaniti for assistance with creating the illustration in Fig. 1.

Author information

Authors and Affiliations

  1. IRCCS MultiMedica, Milan, Italy

    Paola de Candia

  2. Treg Cell Lab, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II”, Naples, Italy

    Giuseppe Matarese

  3. Laboratorio di Immunologia, Istituto per l’Endocrinologia e l’Oncologia Sperimentale “G. Salvatore”, Consiglio Nazionale delle Ricerche (IEOS-CNR), Naples, Italy

    Giuseppe Matarese

Authors
  1. Paola de Candia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Giuseppe Matarese
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Paola de Candia or Giuseppe Matarese.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

de Candia, P., Matarese, G. Reimagining an immunological dogma. Nat Immunol 22, 1355–1358 (2021). https://doi.org/10.1038/s41590-021-01046-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-021-01046-5

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation