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BAtCHing stem-like T cells during exhaustion

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Long-term pathogen and tumor control as well as checkpoint immunotherapies rely on ‘stem-like’ CD8+ T cells. New results uncover BACH2 as a key regulator of this subpopulation and solve an important piece of the puzzle.

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Fig. 1: BACH2 promotes CD8+ T cell differentiation toward Texstem cells while antagonizing Texterm cell fates via epigenetic and transcriptional mechanisms in the early stage of chronic viral infection.

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Acknowledgements

We thank members of the Zúñiga laboratory for their valuable feedback. Research in the Zúñiga laboratory is supported by N.I.H. grants AI145314, AI081923, AI113923 and AI132122. L.L.-B. was partly supported by a ‘La Caixa’ fellowship for studies in North America and by the UCSD Frontiers of Innovation Scholars Program.

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  1. Lara Labarta-Bajo

    Present address: Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA

Authors and Affiliations

  1. Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA

    Lara Labarta-Bajo & Elina I. Zúñiga

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  1. Lara Labarta-Bajo
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  2. Elina I. Zúñiga
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Correspondence to Elina I. Zúñiga.

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Labarta-Bajo, L., Zúñiga, E.I. BAtCHing stem-like T cells during exhaustion. Nat Immunol 22, 274–276 (2021). https://doi.org/10.1038/s41590-021-00891-8

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