Ulrich von Andrian recounts how an unexpected experimental result called into question a well-established concept in immunology: the mechanism of immune memory. Follow-up experiments revealed that NK cells can mediate antigen-specific adaptive immune responses.
References
Morales, A., Eidinger, D. & Bruce, A. W. J. Urol. 116, 180–183 (1976).
Taniguchi, K. et al. Clin. Exp. Immunol. 115, 131–135 (1999).
Ratliff, T. L., Shapiro, A. & Catalona, W. J. Clin. Immunol. Immunopathol. 41, 108–115 (1986).
Redelman-Sidi, G., Glickman, M. S. & Bochner, B. H. Nat. Rev. Urol. 11, 153–162 (2014).
von Andrian, U. H. & Mackay, C. R. N. Engl. J. Med. 343, 1020–1034 (2000).
Asherson, G. L. & Ptak, W. Immunology 15, 405–416 (1968).
Askenase, P. W. Clin. Exp. Immunol. 125, 345–350 (2001).
Elmas, Ö. F., Akdeniz, N., Atasoy, M. & Karadag, A. S. Clin. Dermatol. 38, 176–192 (2020).
Phanuphak, P., Moorhead, J. W. & Claman, H. N. J. Immunol. 112, 849–851 (1974).
O’Leary, J. G., Goodarzi, M., Drayton, D. L. & von Andrian, U. H. Nat. Immunol. 7, 507–516 (2006).
Marchal, G., Seman, M., Milon, G., Truffa-Bachi, P. & Zilberfarb, V. J. Immunol. 129, 954–958 (1982).
Bellavia, A. et al. Int. Arch. Allergy Immunol. 101, 402–407 (1993).
Asherson, G. L., Allwood, G. G. & Mayhew, B. Immunology 25, 485–494 (1973).
Biedermann, T. et al. J. Exp. Med. 192, 1441–1452 (2000).
Jung, D. & Alt, F. W. Cell 116, 299–311 (2004).
Boehncke, W.-H. et al. Exp. Dermatol. 14, 70–80 (2005).
Burnet, F. M. Aust. J. Sci. 20, 67–69 (1957).
Vermijlen, D. et al. J. Leukoc. Biol. 72, 668–676 (2002).
Vermijlen, D. et al. Eur. J. Immunol. 34, 2529–2540 (2004).
Hanke, T. et al. Immunity 11, 67–77 (1999).
Kim, S. et al. Nature 436, 709–713 (2005).
Paust, S. et al. Nat. Immunol. 11, 1127–1135 (2010).
Pancer, Z. et al. Nature 430, 174–180 (2004).
Flajnik, M. F. & Kasahara, M. Immunity 15, 351–362 (2001).
Majewska-Szczepanik, M., Paust, S., von Andrian, U. H., Askenase, P. W. & Szczepanik, M. Immunology 140, 98–110 (2013).
Rouzaire, P. et al. Eur. J. Immunol. 42, 80–88 (2012).
van den Boorn, J. G. et al. Immunity 44, 1406–1421 (2016).
Gillard, G. O. et al. PLoS Pathog. 7, e1002141 (2011); erratum https://doi.org/10.1371/annotation/b29086ef-e08d-444c-8113-18a6dd429a7c (2011).
Habib, S., El Andaloussi, A., Hisham, A. & Ismail, N. PLoS ONE 11, e0153223 (2016).
Sun, J. C., Beilke, J. N. & Lanier, L. L. Nature 457, 557–561 (2009).
Reeves, R. K. et al. Nat. Immunol. 16, 927–932 (2015).
Nikzad, R. et al. Sci. Immunol. 4, eaat8116 (2019).
Foley, B. et al. Blood 119, 2665–2674 (2012).
Milush, J. M. et al. Retrovirology 10, 158 (2013).
Stary, V. et al. Sci. Immunol. 5, eaba6232 (2020).
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von Andrian, U.H. NK cell memory: discovery of a mystery. Nat Immunol 22, 669–671 (2021). https://doi.org/10.1038/s41590-021-00890-9
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DOI: https://doi.org/10.1038/s41590-021-00890-9
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