Skip to main content
SpringerLink
Log in

NUTRITIONAL IMMUNOLOGY

Fiber-poor Western diets fuel inflammation

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

A Publisher Correction to this article was published on 26 April 2021

A Publisher Correction to this article was published on 04 March 2021

This article has been updated

The transition of Sub-Saharan Africans from rural settings and traditional plant-rich diets to urban settings and calorie-dense Westernized diets has led to specific shifts in serum metabolites and activates a heightened proinflammatory state in immune cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Differences in diet cause changes in serum metabolites between rural and urban dwellers, influencing the magnitude of their inflammatory responses.

Change history

References

  1. United Nations Department of Economic and Social Affairs. World Urbanization Prospects: The 2018 Revision. (United Nations, 2019); https://population.un.org/wup/Publications/Files/WUP2018-Report.pdf

  2. Ng, S. C. et al. Gut 62, 630–649 (2013).

    Article  Google Scholar 

  3. Tan, J. K., McKenzie, C., Mariño, E., Macia, L. & Mackay, C. R. Annu. Rev. Immunol. 35, 371–402 (2017).

    Article  CAS  Google Scholar 

  4. Temba, G. S. et al. Nat. Immunol. https://doi.org/10.1038/s41590-021-00867-8 (2021).

  5. Burkitt, D. P. Proc. Nutr. Soc. 32, 145–149 (1973).

    Article  CAS  Google Scholar 

  6. Christ, A. et al. Cell 172, 162–175.e14 (2018).

    Article  CAS  Google Scholar 

  7. Napier, B. A. et al. Proc. Natl Acad. Sci. USA 116, 3688–3694 (2019).

    Article  CAS  Google Scholar 

  8. Gouda, H. N. et al. Lancet Glob. Health 7, e1375–e1387 (2019).

    Article  Google Scholar 

  9. De Filippo, C. et al. Proc. Natl Acad. Sci. USA 107, 14691–14696 (2010).

    Article  Google Scholar 

  10. Zeng, H., Umar, S., Rust, B., Lazarova, D. & Bordonaro, M. Int. J. Mol. Sci. 20, 1214 (2019).

    Article  CAS  Google Scholar 

  11. OʼKeefe, S. J. D. et al. Nat. Commun. 6, 6342 (2015).

    Article  Google Scholar 

  12. Maleki, S. J., Crespo, J. F. & Cabanillas, B. Food Chem. 299, 125124 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Biological Sciences, The University of Chicago, Chicago, IL, USA

    Robert T. Patry & Cathryn R. Nagler

  2. Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, USA

    Cathryn R. Nagler

Authors
  1. Robert T. Patry
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cathryn R. Nagler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Cathryn R. Nagler.

Ethics declarations

Competing interests

C.R.N. is the president and cofounder of ClostraBio, Inc.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Patry, R.T., Nagler, C.R. Fiber-poor Western diets fuel inflammation. Nat Immunol 22, 266–268 (2021). https://doi.org/10.1038/s41590-021-00880-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-021-00880-x

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation