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Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma

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The activation of the Notch4–Wnt–GDF15 axis in induced regulatory T (Treg cells) dampens their immunoregulatory function and turns them into TH2 and TH17 cytokine producers, allowing them to maintain ongoing allergic asthma.

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Fig. 1: Notch4+ Treg cells contribute to TH2 immunity following exposure to allergens and air pollutants.

Debbie Maizels/Springer Nature

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Authors and Affiliations

  1. Laboratory of Mucosal Immunology and Immunoregulation, VIB Center for Inflammation Research, Ghent, Belgium

    Hamida Hammad & Bart N. Lambrecht

  2. Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium

    Hamida Hammad & Bart N. Lambrecht

  3. Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, the Netherlands

    Bart N. Lambrecht

Authors
  1. Hamida Hammad
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  2. Bart N. Lambrecht
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Correspondence to Hamida Hammad.

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The authors declare no competing interests.

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Hammad, H., Lambrecht, B.N. Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma. Nat Immunol 21, 1313–1314 (2020). https://doi.org/10.1038/s41590-020-0797-z

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