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INTRACELLULAR IMMUNITY

Captain GBP1: inflammasomes assemble, pyroptotic endgame

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A Publisher Correction to this article was published on 10 September 2020

This article has been updated

Guanylate-binding proteins (GBPs) promote immune defenses against infectious agents. Two studies reveal that GBP1 directly binds to cytosolic lipopolysaccharide (LPS), bringing caspase-4 to the surface of bacteria to induce pyroptosis.

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Fig. 1: GBP1 binds to cytosolic LPS and initiates the assembly of a signaling platform stabilized by GBP2–4 for the recruitment and activation of caspase-4.

Change history

  • 10 September 2020

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

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Authors and Affiliations

  1. Department of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia

    Shouya Feng & Si Ming Man

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  1. Shouya Feng
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  2. Si Ming Man
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Correspondence to Si Ming Man.

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The authors declare no competing interests.

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Feng, S., Man, S.M. Captain GBP1: inflammasomes assemble, pyroptotic endgame. Nat Immunol 21, 829–830 (2020). https://doi.org/10.1038/s41590-020-0727-0

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