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Foxp3: a genetic foundation for regulatory T cell differentiation and function

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Fred Ramsdell and Alexander Rudensky revisit the discovery of the Foxp3 gene and its foundational role in the differentiation and function of regulatory T cells.

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References

  1. Miller, J. F. Lancet 2, 748–749 (1961).

    Article  CAS  Google Scholar 

  2. Cooper, M. D., Peterson, R. D. A. & Good, R. A. Nature 205, 143–146 (1965).

    Article  CAS  Google Scholar 

  3. Cooper, M. D., Raymond, D. A., Peterson, R. D. A., South, M. A. & Good, R. A. J. Exp. Med. 123, 75–102 (1966).

    Article  CAS  Google Scholar 

  4. Miller, J. F. & Mitchell, G. F. J. Exp. Med. 128, 801–820 (1968).

    Article  CAS  Google Scholar 

  5. Nishizuka, Y. & Sakakura, T. Science 166, 753–755 (1969).

    Article  CAS  Google Scholar 

  6. Kojima, A., Tanaka-Kojima, Y., Sakakura, T. & Nishizuka, Y. Lab. Invest. 34, 601–605 (1976).

    CAS  PubMed  Google Scholar 

  7. Sakaguchi, S., Takahashi, T. & Nishizuka, Y. J. Exp. Med. 156, 1577–1586 (1982).

    Article  CAS  Google Scholar 

  8. Sakaguchi, S., Takahashi, T. & Nishizuka, Y. J. Exp. Med. 156, 1565–1576 (1982).

    Article  CAS  Google Scholar 

  9. Mosmann, T. R. & Coffman, R. L. Annu. Rev. Immunol. 7, 145–173 (1989).

    Article  CAS  Google Scholar 

  10. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. J. Immunol. 155, 1151–1164 (1995).

    CAS  PubMed  Google Scholar 

  11. Brunkow, M. E. et al. Nat. Genet. 27, 68–73 (2001).

    Article  CAS  Google Scholar 

  12. Khattri, R., Cox, T., Yasayko, S.-A. & Ramsdell, F. Nat. Immunol. 4, 337–342 (2003).

    Article  CAS  Google Scholar 

  13. Hori, S., Nomura, T. & Sakaguchi, S. Science 299, 1057–1061 (2003).

    Article  CAS  Google Scholar 

  14. Fontenot, J. D., Gavin, M. A. & Rudensky, A. Y. Nat. Immunol. 4, 330–336 (2003).

    Article  CAS  Google Scholar 

  15. Fontenot, J. D. et al. Immunity 22, 329–341 (2005).

    Article  CAS  Google Scholar 

  16. Gavin, M. A. et al. Nature 445, 771–775 (2007).

    Article  CAS  Google Scholar 

  17. Williams, L. M. & Rudensky, A. Y. Nat. Immunol. 8, 277–284 (2007).

    Article  CAS  Google Scholar 

  18. Bennett, C. L. et al. Nat. Genet. 27, 20–21 (2001).

    Article  CAS  Google Scholar 

  19. Wildin, R. S. et al. Nat. Genet. 27, 18–20 (2001).

    Article  CAS  Google Scholar 

  20. Raffin, C., Vo, L. T. & Bluestone, J. A. Nat. Rev. Immunol. 20, 158–172 (2020).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Fred Ramsdell or Alexander Y. Rudensky.

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Competing interests

F.R. and A.R. are founders and stock holders of Sonoma Biotherapeutics.

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Ramsdell, F., Rudensky, A.Y. Foxp3: a genetic foundation for regulatory T cell differentiation and function. Nat Immunol 21, 708–709 (2020). https://doi.org/10.1038/s41590-020-0694-5

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