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IMMUNODEFICIENCY DISORDERS

Complement inhibitor for therapy of CHAPLE

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A new study shows successful immunotherapy of a detrimental gastrointestinal disease using the complement inhibitor eculizumab.

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Fig. 1: Activation and regulation of complement pathways.

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Acknowledgements

The authors are supported by a National Institute of Arthritis Musculoskeletal and Skin Disease grant (R01 AR073311) from the National Institutes of Health.

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Authors and Affiliations

  1. Abigail Wexner Research Institute and Division of Rheumatology, Nationwide Children’s Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, USA

    Chack-Yung Yu

  2. Department of Pediatrics and Department of Internal Medicine, The Ohio State University, Columbus, OH, USA

    Stacy P. Ardoin

  3. Division of Rheumatology, Nationwide Children’s Hospital and Wexner Medical Center, Columbus, OH, USA

    Stacy P. Ardoin

Authors
  1. Chack-Yung Yu
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  2. Stacy P. Ardoin
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Correspondence to Chack-Yung Yu or Stacy P. Ardoin.

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The authors declare no competing interests.

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Yu, CY., Ardoin, S.P. Complement inhibitor for therapy of CHAPLE. Nat Immunol 22, 106–108 (2021). https://doi.org/10.1038/s41590-020-00842-9

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