Skip to main content
Log in

NEUROIMMUNOLOGY

A new cell subtype that confers neuroprotection

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

A subset of neutrophils with an immature phenotype confers neuroprotection in traumatic optic nerve and spinal cord injury. This study identifies a new target population of cells for therapeutic strategies to induce neural regeneration during injury.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Mature ‘N1’ neutrophils confer neurodegeneration, while immature ‘N2’ neutrophils induce neuroregeneration.

References

  1. Sas, A. R. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-00813-0 (2020).

  2. Miron, V. E. et al. Nat. Neurosci. 16, 1211–1218 (2013).

    Article  CAS  Google Scholar 

  3. Ruckh, J. M. et al. Cell Stem Cell 10, 96–103 (2012).

    Article  CAS  Google Scholar 

  4. Moyon, S. et al. J. Neurosci. 35, 4–20 (2015).

    Article  Google Scholar 

  5. Voskuhl, R. R. et al. Proc. Natl Acad. Sci. USA 116, 10130–10139 (2019).

    Article  CAS  Google Scholar 

  6. Bookheimer, S. Y. et al. Neuroimage 185, 335–348 (2019).

    Article  Google Scholar 

  7. Chai, H. et al. Neuron 95, 531–549.e9 (2017).

    Article  CAS  Google Scholar 

  8. Khakh, B. S. & Sofroniew, M. V. Nat. Neurosci. 18, 942–952 (2015).

    Article  CAS  Google Scholar 

  9. Grabert, K. et al. Nat. Neurosci. 19, 504–516 (2016).

    Article  CAS  Google Scholar 

  10. Marques, S. et al. Science 352, 1326–1329 (2016).

    Article  CAS  Google Scholar 

  11. Itoh, N. et al. Proc. Natl Acad. Sci. USA 115, E302–E309 (2018).

    Article  CAS  Google Scholar 

  12. Tassoni, A. et al. Sci. Rep. 9, 10010 (2019).

    Article  Google Scholar 

  13. Yan, Z. et al. JCI Insight 5, e126520 (2019).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rhonda Voskuhl.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Voskuhl, R. A new cell subtype that confers neuroprotection. Nat Immunol 21, 1477–1478 (2020). https://doi.org/10.1038/s41590-020-00821-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-020-00821-0

  • Springer Nature America, Inc.

Navigation