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STERILE INFLAMMATION

ApoC3: an ‘alarmin’ triggering sterile inflammation

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NLRP3-driven sterile inflammation facilitates the pathogenesis of various human inflammatory diseases. New work identifies apolipoprotein C3 as an endogenous NLRP3 agonist that promotes sterile inflammation and organ damage.

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Fig. 1: Role of ApoC3 in sterile inflammation.

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Authors and Affiliations

  1. Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China

    Tao Gong & Rongbin Zhou

  2. CAS Centre for Excellence in Cell and Molecular Biology, University of Science and Technology of China, Hefei, China

    Rongbin Zhou

Authors
  1. Tao Gong
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  2. Rongbin Zhou
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Correspondence to Rongbin Zhou.

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The authors declare no competing interests.

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Gong, T., Zhou, R. ApoC3: an ‘alarmin’ triggering sterile inflammation. Nat Immunol 21, 9–11 (2020). https://doi.org/10.1038/s41590-019-0562-3

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