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INTESTINAL VIROME

Viruses RIG up intestinal immunity

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The virome, increasingly recognized as a critical component of the mammalian microbiota, modulates host physiology. An antiviral treatment approach reveals that, via RIG-I signaling, the commensal virome is essential for the homeostasis of intestinal intraepithelial lymphocytes.

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Fig. 1: RIG-I-mediated sensing of commensal viruses stimulates IEL homeostasis.

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Authors and Affiliations

  1. Department of Medicine, Division of Infectious Diseases, Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St. Louis, MO, USA

    Sanghyun Lee & Megan T. Baldridge

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  1. Sanghyun Lee
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  2. Megan T. Baldridge
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Correspondence to Megan T. Baldridge.

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The authors declare no competing interests.

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Lee, S., Baldridge, M.T. Viruses RIG up intestinal immunity. Nat Immunol 20, 1563–1564 (2019). https://doi.org/10.1038/s41590-019-0530-y

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