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T CELL PROTEOMICS

TCR signaling: it’s all about the numbers

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Quantitative mass spectrometry applied to T cell activation reveals key insights into signal-transduction pathways. These data identify selective alterations in the concentration of proteins in activated T cells and detail previously undescribed protein–protein interactions.

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Fig. 1: Analysis of the stoichiometry of global protein levels and protein–protein interactions by quantitative mass spectrometry in primary T cells.

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Authors and Affiliations

  1. Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, USA

    James M. Conley & Leslie J. Berg

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  1. James M. Conley
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  2. Leslie J. Berg
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Correspondence to Leslie J. Berg.

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The authors declare no competing interests.

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Conley, J.M., Berg, L.J. TCR signaling: it’s all about the numbers. Nat Immunol 20, 1415–1416 (2019). https://doi.org/10.1038/s41590-019-0520-0

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  • DOI: https://doi.org/10.1038/s41590-019-0520-0

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