Cellular metabolic screening identifies hyper-respiration, induced by gain-of-function mutations in the gene encoding succinate dehydrogenase, as a disease-driving immunometabolic trait of B cells from patients with primary antibody deficiency.
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References
Burgener, A. V. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0482-2 (2019).
Caro-Maldonado, A. et al. J. Immunol. 192, 3626–3636 (2014).
Doughty, C. A. et al. Blood 107, 4458–4465 (2006).
Cho, S. H. et al. Proc. Natl Acad. Sci. USA 108, 15972–15977 (2011).
Dufort, F. J. et al. J. Biol. Chem. 289, 7011–7024 (2014).
Jellusova, J. et al. Nat. Immunol. 18, 303–312 (2017).
Waters, L.R. et al. iScience 5, 99–109 (2018).
Akkaya, M. et al. Nat. Immunol. 19, 871–884 (2018).
Jang, K. J. et al. Nat. Commun. 6, 6750 (2015).
Ogura, M. et al. Eur. J. Immunol. 47, 406–418 (2017).
Durandy, A., Kracker, S. & Fischer, A. Nat. Rev. Immunol. 13, 519–533 (2013).
Kornberg, M. D. et al. Science 360, 449–453 (2018).
Garraud, O. et al. BMC Immunol. 13, 63 (2012).
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Zeng, H., Chi, H. Metabolic sleuthing solves a rare immunodeficiency disease. Nat Immunol 20, 1264–1266 (2019). https://doi.org/10.1038/s41590-019-0499-6
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DOI: https://doi.org/10.1038/s41590-019-0499-6
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