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ZIKA VACCINE

When it is better to stay together

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A specifically engineered Zika subunit vaccine based on the viral envelope protein mediates protective immunity in mice without inducing the cross-reactive antibodies responsible for antibody-dependent enhancement of infection with dengue virus.

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Fig. 1: Structural background for the Zika E dimer vaccine stabilized by three disulfide bridges to prevent E dimer dissociation and exposure of the fusion loop.

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Authors and Affiliations

  1. Center for Virology, Medical University of Vienna, Vienna, Austria

    Franz X. Heinz & Karin Stiasny

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  1. Franz X. Heinz
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  2. Karin Stiasny
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Correspondence to Franz X. Heinz.

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The authors declare no competing interests.

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Heinz, F.X., Stiasny, K. When it is better to stay together. Nat Immunol 20, 1266–1268 (2019). https://doi.org/10.1038/s41590-019-0497-8

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