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INTERLEUKIN 15

IL-15 in autoimmunity and cancer: O-tu-b or not O-tu-b?

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The cytokine IL-15 controls the homeostasis and activation of CD8+ T cells and natural killer cells. A new study reveals the deubiquitinase Otub1 to be a negative regulator of IL-15 signaling, with important consequences for autoimmunity and anti-cancer immunity.

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Fig. 1: Otub1 negatively regulates IL-15 signaling in CD8+ T cells and NK cells.

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Authors and Affiliations

  1. Department of Biology, Maynooth University Human Health Research Institute, National University of Ireland Maynooth, Maynooth, Ireland

    Paul N. Moynagh

  2. Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queen’s University Belfast, Belfast, UK

    Paul N. Moynagh

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  1. Paul N. Moynagh
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Correspondence to Paul N. Moynagh.

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Moynagh, P.N. IL-15 in autoimmunity and cancer: O-tu-b or not O-tu-b?. Nat Immunol 20, 780–782 (2019). https://doi.org/10.1038/s41590-019-0424-z

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