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REGULATORY RNA

CIRCling the wagons to protect intestinal stem cells

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Innate lymphoid cell–derived cytokine IL-13 promotes the maintenance of intestinal stem cells through stabilization of β-catenin. The circular RNA circPan3 regulates mRNA encoding the cytokine receptor subunit IL-13Rα and downstream IL-13 signaling to stabilize the β-catenin pathway in intestinal stem cells.

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Fig. 1: Role of circPan3 in ISC regulation.

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Authors and Affiliations

  1. Department of Immunology, School of Medicine, University of Washington, Seattle, WA, USA

    Frank Soveg, Jakob von Moltke & Ram Savan

Authors
  1. Frank Soveg
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  2. Jakob von Moltke
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  3. Ram Savan
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Corresponding author

Correspondence to Ram Savan.

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The authors declare no competing interests.

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Soveg, F., von Moltke, J. & Savan, R. CIRCling the wagons to protect intestinal stem cells. Nat Immunol 20, 114–116 (2019). https://doi.org/10.1038/s41590-018-0302-0

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