Skip to main content

Advertisement

SpringerLink
Log in

INNATE IMMUNITY

STIM1 moonlights as an anchor for STING

  • News & Views
  • Published:

From Nature Immunology

View current issue Submit your manuscript

Activation of STING requires its translocation from the endoplasmic reticulum (ER) through the Golgi to vesicles, but the mechanisms that control its localization have been unclear. The ER calcium sensor STIM1 acts as an ER-retention factor that anchors STING on the ER and limits STING signaling.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: STIM1 is an ER-retention factor for STING.

References

  1. Yan, N. J. Interferon Cytokine Res. 37, 198–206 (2017).

    Article  CAS  Google Scholar 

  2. Weichselbaum, R. R., Liang, H., Deng, L. & Fu, Y.-X. Nat. Rev. Clin. Oncol. 14, 365–379 (2017).

    Article  CAS  Google Scholar 

  3. Gonugunta, V. K. et al. Cell Reports 21, 3234–3242 (2017).

    Article  CAS  Google Scholar 

  4. Dobbs, N. et al. Cell Host Microbe 18, 157–68 (2015).

    Article  CAS  Google Scholar 

  5. Srikanth, S. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0287-8 (2018).

    Article  Google Scholar 

  6. Luo, W.-W. et al. Nat. Immunol. 17, 1057–1066 (2016).

    Article  CAS  Google Scholar 

  7. Wang, Q. et al. Immunity 41, 919–933 (2014).

    Article  CAS  Google Scholar 

  8. Chen, W. et al. PLoS Pathog. 12, e1005462 (2016).

    Article  Google Scholar 

  9. Zhou, Q. et al. Cell Host Microbe 16, 450–461 (2014).

    Article  CAS  Google Scholar 

  10. Liou, J. et al. Curr. Biol. 15, 1235–1241 (2005).

    Article  CAS  Google Scholar 

  11. Prakriya, M. & Lewis, R. S. Physiol. Rev. 95, 1383–1436 (2015).

    Article  CAS  Google Scholar 

  12. Picard, C. et al. N. Engl. J. Med. 360, 1971–1980 (2009).

    Article  CAS  Google Scholar 

  13. Lacruz, R. S. & Feske, S. Ann. NY Acad. Sci. 1356, 45–79 (2015).

    Article  CAS  Google Scholar 

  14. Warner, J. D. et al. J. Exp. Med. 214, 3279 (2017).

    Article  CAS  Google Scholar 

  15. Kim, S., Koch, P., Li, L., Peshkin, L. & Mitchison, T. J. bioRxiv. https://doi.org/10.1101/145854 (2017).

    Article  Google Scholar 

  16. Bouis, D. et al. J. Allergy Clin. Immunol. https://doi.org/10.1016/j.jaci.2018.04.034 (2018).

Download references

Author information

Authors and Affiliations

  1. Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Jianjun Wu & Nan Yan

  2. Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Nan Yan

Authors
  1. Jianjun Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nan Yan
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nan Yan.

Ethics declarations

Competing interests

The authors declare no competing interests

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, J., Yan, N. STIM1 moonlights as an anchor for STING. Nat Immunol 20, 112–114 (2019). https://doi.org/10.1038/s41590-018-0300-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-018-0300-2

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation